Highlights beim myelodysplastischen Syndrom

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Hochrisiko-MDS

Immuntherapie

  • Anti-CD47-Antikörper Magrolimab

The First-In-Class Anti-CD47 Antibody Magrolimab Combined With Azacitidine Is Well-Tolerated And Effective In MDS Patients: Phase 1b Results. Sallman David et al., EHA25 virtual, Abstr. #S187

  • Anti-Tim-3-Antikörper MBG453

Anti-TIM-3 Antibody MBG453 In Combination With Hypomethylating Agents (HMAs) In Patients (Pts) With High-Risk Myelodysplastic Syndrome (HR-MDS) And Acute Myeloid Leukemia (AML): A Phase 1 Study. Uma Borate et al., EHA25 virtual, #Abstr S185

Zielgerichtete Therapie

  • APR-246Target ist mutiertes p53

APR-246 Combined With Azacitidine In Tp53 Mutated Myelodysplastic Syndromes (MDS) And Acute Myeloid Leukemia. A Phase 2 Study By The Groupe Francophone Des Myélodysplasies (GFM). Thomas Cluzeau et al., EHA25 virtual, Abstr. # S181

  • bcl2-Hemmer Venetoclax

A Phase 1b Study Evaluating The Safety And Efficacy Of Venetoclax In Combination With Azacitidine For The Treatment Of Relapsed/Refractory Myelodysplastic Syndrome. Amer M. Zeidan et al., EHA25 virtual, Abstr. #S188

  • Proteasomeninhibitor Pevonedistat

Phase 2 Study Of Pevonedistat + Azacitidine Versus Azacitidine In Patients With Higher-Risk Myelodysplastic Syndromes/Chronic Myelomonocytic Leukemia Or Low-Blast Acute Myelogenous Leukemia. Lionel Ades et al., EHA25 virtual, Abstr. #S182

Niedrigrisiko-MDS

  • Luspatercept bei hoher Transfusionslast – Auswertung der MEDALIST-Studie (Zeidan et al.)

Clinical Benefit Of Luspatercept In Patients With Lower-Risk Myelodysplastic Syndromes (LR-MDS) And High Transfusion Burden (HTB) In The Phase 3 MEDALIST Study. Amer M. Zeidan et al., EHA25 virtual, Abstr. # EP798

  • Dosisabhängiges Ansprechen auf Luspatercept – Auswertung der MEDALIST-Studie (Platzbecker et al.)

Assessment Of Dose-Dependent Response To Luspatercept In Patients (Pts) With Lower-Risk Myelodysplastic Syndromes (LR-MDS) With Ring Sideroblasts In The Phase 3 MEDALIST Trial. Uwe Platzbecker et al., EHA25 virtual, Abstr. #EP812

  • Telomerase-Inhibitor Imetelstat 

https://library.ehaweb.org/eha/2020/eha25th/295003/uwe.platzbecker.treatment.with.imetelstat.provides.durable.transfusion.html?f=listing%3D0%2Abrowseby%3D8%2Asortby%3D1%2Asearch%3Dtelomerase+inhibitor