Small Airways Disease – müssen wir die kleinen Atemwege therapieren?

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AutorIn: Dr. Katharina Marth

Abteilung für Atmungs- und Lungenerkrankungen, Krankenhaus Hietzing mit Neurologischem Zentrum Rosenhügel, Wien


AutorIn: Prim. Univ.-Prof. Dr. Wolfgang Pohl

Abteilung für Atmungs- und Lungenerkrankungen, Krankenhaus Hietzing mit Neurologischem Zentrum Rosenhügel, Wien


1 Green M. How big are the bronchioles? St Thomas Hosp Gaz 1964; 62:136–139
2 Hogg JC et al., Site and nature of airway obstruction in chronic obstructive lung disease. N Engl J Med 1968; 278:1355–1360
3 Wagner EM et al., Peripheral lung resistance in normal and asthmatic subjects. Am Rev Respir Dis 1990; 141:584–588
4 In’t Veen JC et al., Recurrent exacerbations in severe asthma are associated with enhanced airway closure during stable episodes. Am J Respir Crit Care Med 2000; 161:1902–1906
5 Kraft M et al., Distal lung dysfunction at night in nocturnal asthma. Am J Respir Crit Care Med 2001; 163:1551–1556
6 Zeidler MR et al., Small airways response to naturalistic cat allergen exposure in subjects with asthma. J Allergy Clin Immunol 2006; 118:1075–1081
7 Hogg JC et al., The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004; 350:2645–2653
8 Niewoehner DE et al., Pathologic changes in the peripheral airways of young cigarette smokers. N Engl J Med 1974; 291:755–758
9 Baraldo S et al., Pathophysiology of the small airways in chronic obstructive pulmonary disease. Respiration 2012; 84:89–97
10 Saetta M et al., CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999; 160:711–717
11 Lams BE et al., Immunopathology of the small-airway submucosa in smokers with and without chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998; 158:1518–1523.
12 Saha S et al., Eosinophilic airway inflammation in COPD. Int J Chron Obstruct Pulmon Dis 2006; 1:39–47
13 Lucidarme O et al., Expiratory CT scans for chronic airway disease: correlation with pulmonary function test results. AJR Am J Roentgenol 1998; 170:301–307
14 van Veen ICH et al., Alveolar nitric oxide versus measures of peripheral airway dysfunction in severe asthma. Eur Respir J 2006; 27:951–956
15 Robinson PD et al., Inert gas washout: theoretical background and clinical utility in respiratory disease. Respiration 2009; 78:339–355
16 Takeda T et al., Relationship between small airway function and health status, dyspnea and disease control in asthma. Respiration 2010; 80:120–126
17 Vikgren J et al., Value of air trapping in detection of small airways disease in smokers. Acta Radiol 2003; 44:517–524
18 Bauman G et al., Non-contrast-enhanced perfusion and ventilation assessment of the human lung by means of fourier decomposition in proton MRI. Magn Reson Med 2009; 62:656–664
19 Usmani OS et al., Regional lung deposition and bronchodilator response as a function of beta2-agonist particle size. Am J Respir Crit Care Med 2005; 172:1497–1504
20 Papi A et al., Beclomethasone/formoterol vs fluticasone/salmeterol inhaled combination in moderate to severe asthma. Allergy 2007; 62:1182–1188
21 Boulet LP et al., A randomized study comparing ciclesonide and fluticasone propionate in patients with moderate persistent asthma. Respir Med 2007; 101:1677–1686
22 Scichilone N et al., Effects of extra-fine inhaled beclomethasone/formoterol on both large and small airways in asthma. Allergy 2010; 65:897–902
23 Yamaguchi M et al., Effect of inhaled corticosteroids on small airways in asthma: investigation using impulse oscillometry. Pulm Pharmacol Ther 2009; 22:326–332
24 Cohen J et al., Ciclesonide improves measures of small airway involvement in asthma. Eur Respir J 2008; 31:1213–1220
25 Barnes N et al., Asthma control with extrafine-particle hydrofluoroalkane-beclometasone vs. large-particle chlorofluorocarbon-beclometasone: a real-world observational study. Clin Exp Allergy 2011; 41:1521–1532

UIM 09|2014

Herausgeber: o. Univ.-Prof. Dr. Günter J. Krejs, Österreichische Gesellschaft für Innere Medizin
Publikationsdatum: 2014-12-16